Concentrations of various antibiotics in serum and fluids accumulated in diffusion chambers implanted in various sites in rabbits | Zendy

Apostolos P. Georgopoulos | Zendy; E Schütze | Zendy

Open Access

Concentrations of various antibiotics in serum and fluids accumulated in diffusion chambers implanted in various sites in rabbits

Author(s) -

Apostolos P. Georgopoulos,

E Schütze

Publication year - 1980

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.17.5.779

Subject(s) - cefazolin , gentamicin , antibiotics , chemistry , azlocillin , ampicillin , pharmacokinetics , diffusion , pharmacology , medicine , biology , bacteria , biochemistry , physics , thermodynamics , pseudomonas aeruginosa , genetics , piperacillin

Diffusion chambers with Millipore membranes were implanted in soft tissue, kidneys, and peritoneal and pleural cavities of rabbits. Single doses of azlocillin, cefazolin, and gentamicin were injected intramuscularly and ampicillin was administered orally 2--5 weeks after implantation. The concentrations of the respective drugs in simultaneously collected samples of fluid from each diffusion chamber were measured and compared with concentrations found at the same time in serum. All chambers were tolerated well, and the method proved to be effective for collecting data on the distribution of drugs throughout the body.

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