Open AccessIn vitro susceptibility of Clostridium difficile isolates from patients with antibiotic-associated diarrhea or colitis
Author(s) -
J. L. Dzink,
John G. Bartlett
Publication year - 1980
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.17.4.695
Subject(s) - microbiology and biotechnology , clindamycin , ampicillin , clostridium difficile , metronidazole , penicillin , antibiotics , diarrhea , antimicrobial , antibiotic associated diarrhea , vancomycin , colitis , clostridium , pseudomembranous colitis , cefotaxime , biology , medicine , bacteria , immunology , staphylococcus aureus , genetics
In vitro susceptibility tests were performed on 84 strains of Clostridium difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin. Over 95% of the strains were susceptible to vancomycin, penicillin G, ampicillin, and metronidazole at concentrations of 4 microgram/ml. Susceptibility to clindamycin was variable; 60% of the strains were susceptible at 1 microgram/ml, and 9% were resistant at 128 microgram/ml. Studies of individual isolates showed that a major portion of the strains were relatively susceptible to the antimicrobial agent implicated in causing the disease.