Open AccessAntibacterial activity of ceftizoxime, a beta-lactamase-stable cephalosporin
Author(s) -
Kwung P. Fu,
Harold C. Neu
Publication year - 1980
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.17.4.583
Subject(s) - ceftizoxime , cefotaxime , cefoxitin , carbenicillin , microbiology and biotechnology , cefoperazone , proteus vulgaris , enterobacter aerogenes , proteus mirabilis , cefamandole , enterobacter , enterobacter cloacae , cephalosporin , chemistry , biology , pseudomonas aeruginosa , enterobacteriaceae , antibiotics , staphylococcus aureus , gentamicin , escherichia coli , imipenem , antibiotic resistance , bacteria , biochemistry , genetics , gene
The in vitro activity of ceftizoxime was compared with that of other beta-lactam antibiotics against 538 isolates. Ceftizoxime was the most active agent tested against Escherichia coli and Klebsiella, inhibiting 80% at 0.025 microgram/ml. It was more active than cefotaxime against Enterobacter cloacae and E. aerogenes. Ceftizoxime was more active than cefoxitin, cefotaxime, cefoperazone, and carbenicillin against Proteus mirabilis and indole-positive Proteus. It inhibited 97% of multiresistant Serratia isolates at 12.5 microgram/ml, whereas cefotaxime inhibited only 19%. Ceftizoxime was less active than cefotaxime and cefoperazone against Pseudomonas aeruginosa, but was more active than carbenicillin. It was more active than cefotaxime and cefoxitin against Bacteroides. It was not appreciably destroyed by beta-lactamases of Staphylococcus aureus, Enterobacteriaceae, or Pseudomonas.