Open AccessBactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against gram-negative bacilli
Author(s) -
J. Michel,
J. Jacobs,
T. Sacks
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.16.6.761
Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , antibiotics , antimicrobial , antagonism , biology , escherichia coli , bacilli , gram negative bacteria , bacteria , antibacterial activity , proteus , enterobacteriaceae , klebsiella , fosfomycin , biochemistry , genetics , receptor , gene
Six antineoplastic antibiotics showed little antibacterial activity against 28 strains of four species of gram-negative enteric bacteria. By using the cellophane transfer technique, combinations of these agents with 16 antibacterial drugs usually showed indifference. However, combinations of mitomycin C, especially with the aminoglycosides, were synergistic on strains of Escherichia coli, Proteus, and Klebsiella pneumoniae. Bleomycin, on the other hand, often showed antagonism on strains of E. coli and K. pneumoniae with the beta-lactams, aminoglycosides, and other antibacterial agents. Checkerboard titrations and kinetic killing curves confirmed these findings.