Erythromycin and clindamycin resistance in Corynebacterium diphtheriae from skin lesions
Author(s) -
M B Coyle,
Barbara H. Minshew,
Judith A. Bland,
PeiChi Hsu
Publication year - 1979
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.16.4.525
Subject(s) - erythromycin , clindamycin , microbiology and biotechnology , corynebacterium diphtheriae , antibiotics , microgram , biology , diphtheria , virology , in vitro , biochemistry , vaccination
Erythromycin- and clindamycin-resistant Corynebacterium diphtheriae isolates were recovered from skin lesions. Resistance to erythromycin and clindamycin was induced by a subinhibitory concentration (0.03 microgram/ml) of erythromycin. Clindamycin (0.07 microgram/ml) was a more effective inducer of its own resistance than of erythromycin resistance. Erythromycin-inducible cross-resistance to vernamycin B alpha was demonstrated in disk diffusion tests.
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