Open AccessWhole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
Author(s) -
Beatriz MengualChuliá,
Andrés Alonso-Cordero,
Laura Cano,
Marı́a del Mar Mosquera,
P. Molina,
Roser Vendrell,
Mariana Reyes-Prieto,
Mireia Jané,
Núria Torner,
Ana Isabel Martínez,
Jordi Vilà,
Javier DíezDomingo,
M Ángeles Marcos,
F. Xavier LópezLabrador
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02718-20
Subject(s) - virology , genome , biology , virus , polymerase chain reaction , polymerase , influenza a virus , orthomyxoviridae , whole genome sequencing , genetics , gene
Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.