Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019 | Zendy

Beatriz MengualChuliá | Zendy; Andrés Alonso-Cordero | Zendy; Laura Cano | Zendy; Mar Mosquera | Zendy; Patricia Molina | Zendy; Roser Vendrell | Zendy; Mariana ReyesPrieto | Zendy; Mireia Jané | Zendy; Núria Torner | Zendy; Ana I. Martı́nez | Zendy; Jordi Vilà | Zendy; Javier DíezDomingo | Zendy; M. Ángeles Marcos | Zendy; F. Xavier LópezLabrador | Zendy

Open Access

Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019

Author(s) -

Beatriz MengualChuliá,

Andrés Alonso-Cordero,

Laura Cano,

Mar Mosquera,

Patricia Molina,

Roser Vendrell,

Mariana ReyesPrieto,

Mireia Jané,

Núria Torner,

Ana I. Martı́nez,

Jordi Vilà,

Javier DíezDomingo,

M. Ángeles Marcos,

F. Xavier LópezLabrador

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02718-20

Subject(s) - virology , genome , biology , virus , polymerase chain reaction , polymerase , influenza a virus , orthomyxoviridae , whole genome sequencing , genetics , gene

Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.

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