Open AccessImpact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-Resistant Staphylococcus aureus
Author(s) -
Selvi C. Ersoy,
Henry F. Chambers,
Richard A. Proctor,
Adriana E. Rosato,
Nagendra N. Mishra,
Yan Xiong,
Arnold S. Bayer
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02621-20
Subject(s) - staphylococcus aureus , methicillin resistant staphylococcus aureus , in vivo , microbiology and biotechnology , sccmec , in vitro , gene , biology , phenotype , bacteria , biochemistry , genetics
Certain methicillin-resistant Staphylococcus aureus (MRSA) strains exhibit β-lactam susceptibility in vitro , ex vivo , and in vivo in the presence of NaHCO 3 (NaHCO 3 -responsive MRSA). Here, we investigate the impact of NaHCO 3 on factors required for PBP2a functionality.