Open AccessImportation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada
Author(s) -
Alireza Eshaghi,
Sandra Zittermann,
Amrita Bharat,
Michael R. Mulvey,
Vanessa Allen,
Samir N. Patel
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02581-19
Subject(s) - typhoid fever , outbreak , salmonella typhi , serotype , azithromycin , salmonella enterica , medicine , virology , salmonella , drug resistance , microbiology and biotechnology , antibiotics , biology , bacteria , gene , genetics , escherichia coli
A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections ( n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were genetically related to the Pakistan outbreak strain. The appearance of XDR typhoid cases in Ontario prompted a provincial wide alert to physicians to recommend treatment with carbapenems or azithromycin in suspected typhoid cases with travel history to Pakistan.