Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada | Zendy

Alireza Eshaghi | Zendy; Sandra Zittermann | Zendy; Amrita Bharat | Zendy; Michael R. Mulvey | Zendy; Vanessa Allen | Zendy; Samir N. Patel | Zendy

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Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada

Author(s) -

Alireza Eshaghi,

Sandra Zittermann,

Amrita Bharat,

Michael R. Mulvey,

Vanessa Allen,

Samir N. Patel

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02581-19

Subject(s) - typhoid fever , outbreak , salmonella typhi , serotype , azithromycin , salmonella enterica , medicine , virology , salmonella , drug resistance , microbiology and biotechnology , antibiotics , biology , bacteria , gene , genetics , escherichia coli

A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections ( n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were genetically related to the Pakistan outbreak strain. The appearance of XDR typhoid cases in Ontario prompted a provincial wide alert to physicians to recommend treatment with carbapenems or azithromycin in suspected typhoid cases with travel history to Pakistan.

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