Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis | Zendy

Charles Omollo | Zendy; Vinayak Singh | Zendy; Elizabeth Kigondu | Zendy; Antonina Wasuna | Zendy; Pooja Agarwal | Zendy; A. Moosa | Zendy; Thomas R. Ioerger | Zendy; Valerie Mizrahi | Zendy; Kelly Chibale | Zendy; Digby F. Warner | Zendy

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Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis

Author(s) -

Charles Omollo,

Vinayak Singh,

Elizabeth Kigondu,

Antonina Wasuna,

Pooja Agarwal,

A. Moosa,

Thomas R. Ioerger,

Valerie Mizrahi,

Kelly Chibale,

Digby F. Warner

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02554-20

Subject(s) - mycobacterium tuberculosis , rifampicin , isoniazid , tuberculosis , drug resistance , microbiology and biotechnology , biology , antibiotics , pharmacology , medicine , pathology

Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tuberculosis .

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