Open AccessDeveloping Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis
Author(s) -
Charles Onyango Omollo,
Vinayak Singh,
Elizabeth Kigondu,
Antonina Wasuna,
Pooja Agarwal,
A Moosa,
Thomas R. Ioerger,
Valerie Mizrahi,
Kelly Chibale,
Digby F. Warner
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02554-20
Subject(s) - mycobacterium tuberculosis , rifampicin , isoniazid , tuberculosis , drug resistance , microbiology and biotechnology , biology , antibiotics , pharmacology , medicine , pathology
Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tuberculosis .