Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus | Zendy

Clément Raynaud | Zendy; Wassim Daher | Zendy; Françoise Roquet-Banères | Zendy; Matt D. Johansen | Zendy; Jozef Stec | Zendy; Oluseye K. Onajole | Zendy; Diane Ordway | Zendy; Alan P. Kozikowski | Zendy; Laurent Kremer | Zendy

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Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus

Author(s) -

Clément Raynaud,

Wassim Daher,

Françoise Roquet-Banères,

Matt D. Johansen,

Jozef Stec,

Oluseye K. Onajole,

Diane Ordway,

Alan P. Kozikowski,

Laurent Kremer

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02548-19

Subject(s) - cefoxitin , mycobacterium abscessus , imipenem , microbiology and biotechnology , antibiotics , in vitro , indole test , pharmacology , chemistry , mycobacterium , medicine , biology , bacteria , antibiotic resistance , biochemistry , staphylococcus aureus , genetics

New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.

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