Open AccessSynergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus
Author(s) -
Clément Raynaud,
Wassim Daher,
Françoise Roquet-Banères,
Matt D. Johansen,
Jozef Stec,
Oluseye K. Onajole,
Diane Ordway,
Alan P. Kozikowski,
Laurent Kremer
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02548-19
Subject(s) - cefoxitin , mycobacterium abscessus , imipenem , microbiology and biotechnology , antibiotics , in vitro , indole test , chemistry , mycobacterium , pharmacology , medicine , biology , bacteria , antibiotic resistance , stereochemistry , biochemistry , staphylococcus aureus , genetics
New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.