Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy | Zendy

Sarah Israel | Zendy; Hila Elinav | Zendy; Ram Elazary | Zendy; Daniel Porat | Zendy; Roni Gibori | Zendy; Arik Dahan | Zendy; Carmil Azran | Zendy; Ehud Horwitz | Zendy

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Case Report of Increased Exposure to Antiretrovirals following Sleeve Gastrectomy

Author(s) -

Sarah Israel,

Hila Elinav,

Ram Elazary,

Daniel Porat,

Roni Gibori,

Arik Dahan,

Carmil Azran,

Ehud Horwitz

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02453-19

Subject(s) - abacavir , sleeve gastrectomy , dolutegravir , medicine , lamivudine , antiretroviral drug , morbidly obese , surgery , gastrectomy , human immunodeficiency virus (hiv) , drug , obesity , weight loss , antiretroviral therapy , viral load , pharmacology , virology , gastric bypass , virus , cancer , hepatitis b virus

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ∼12-fold. Several mechanistic explanations for these findings are discussed.

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