Open AccessVaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae
Author(s) -
Lance R. Fredericks,
Mark D. Lee,
Hannah R Eckert,
Shunji Li,
Mason Shipley,
Cooper R. Roslund,
Dina Boikov,
Emily A. Kizer,
Jack D. Sobel,
Paul A. Rowley
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02450-20
Subject(s) - candida glabrata , microbiology and biotechnology , saccharomyces cerevisiae , biology , fungi imperfecti , candida albicans , yeast , biochemistry
Compared to other species ofCandida yeasts, the growth ofCandida glabrata was inhibited by many different strains ofSaccharomyces killer yeasts. The ionophoric K1 and K2 killer toxins were broadly inhibitory to all clinical isolates ofC. glabrata from patients with recurrent vulvovaginal candidiasis despite high levels of resistance to clinically relevant antifungal therapeutics.