Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles | Zendy

Martijn Zwama | Zendy; Kunihiko Nishino | Zendy

Open Access

Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles

Author(s) -

Martijn Zwama,

Kunihiko Nishino

Publication year - 2022

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02392-21

Subject(s) - efflux , novobiocin , cloxacillin , escherichia coli , salmonella enterica , microbiology and biotechnology , azithromycin , antibiotics , biology , enterobacteriaceae , multidrug resistance associated proteins , multiple drug resistance , atp binding cassette transporter , genetics , gene , ampicillin , transporter

Recent mutations in RND efflux pumps in clinical strains have further increased multidrug resistance. We show that R717L and R717Q substitutions (found in azithromycin-resistantSalmonella enterica spp.) in theEscherichia coli efflux pump AcrB dramatically increase macrolide, as well as fluoroquinolone, resistance.

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