Open AccessHydrogen Peroxide-Generating Electrochemical Scaffold Activity against Trispecies Biofilms
Author(s) -
Yash S. Raval,
Abdelrhman Mohamed,
Jakyoung Song,
Kerryl E. GreenwoodQuaintance,
Haluk Beyenal,
Robin Patel
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02332-19
Subject(s) - biofilm , hydrogen peroxide , pseudomonas aeruginosa , scaffold , candida albicans , chemistry , staphylococcus aureus , microbiology and biotechnology , electrochemistry , bacteria , biology , biochemistry , electrode , biomedical engineering , medicine , genetics
The antibiofilm activity of a hydrogen peroxide-generating electrochemical scaffold (e-scaffold) was determined against mono- and trispecies biofilms of methicillin-resistant Staphylococcus aureus , multidrug-resistant Pseudomonas aeruginosa , and Candida albicans Significant time-dependent decreases were found in the overall CFU of biofilms of all three monospecies and the trispecies forms. Confocal laser scanning microscopy showed dramatic reductions in fluorescence intensities of biofilm matrix protein and polysaccharide components of e-scaffold-treated biofilms. The described e-scaffold has potential as a novel antibiotic-free strategy for treating wound biofilms.