Open AccessA Novel Plasmid Entry Exclusion System in pKPC_UVA01, a Promiscuous Conjugative Plasmid Carrying the bla KPC Carbapenemase Gene
Author(s) -
Muhammad Kamruzzaman,
Amy J Mathers,
Jonathan R. Iredell
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02322-21
Subject(s) - plasmid , biology , bacterial conjugation , gene , bacteria , genetics , escherichia coli , horizontal gene transfer , microbiology and biotechnology , genome
Conjugative plasmids are the principal mediator in the emergence and spread of antibiotic resistance genes in Enterobacterales. Plasmid entry exclusion (EEX) systems can restrict their transfer into the recipient bacteria carrying closely related plasmids.