Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments | Zendy

Christian Dide-Agossou | Zendy; Allison Bauman | Zendy; Michelle E. Ramey | Zendy; Karen Rossmassler | Zendy; Reem Al Mubarak | Zendy; Samantha Pauly | Zendy; Martin I. Voskuil | Zendy; Maria GarciaCremades | Zendy; Rada Savic | Zendy; Payam Nahid | Zendy; Camille M. Moore | Zendy; Rokeya Tasneen | Zendy; Eric L. Nuermberger | Zendy; Gregory T. Robertson | Zendy; Nicholas D. Walter | Zendy

Open Access

Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments

Author(s) -

Christian Dide-Agossou,

Allison Bauman,

Michelle E. Ramey,

Karen Rossmassler,

Reem Al Mubarak,

Samantha Pauly,

Martin I. Voskuil,

Maria GarciaCremades,

Rada Savic,

Payam Nahid,

Camille M. Moore,

Rokeya Tasneen,

Eric L. Nuermberger,

Gregory T. Robertson,

Nicholas D. Walter

Publication year - 2022

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02310-21

Subject(s) - mycobacterium tuberculosis , tuberculosis , drug , microbiology and biotechnology , medicine , antibiotics , pharmacology , biology , virology , pathology

Murine tuberculosis drug efficacy studies have historically monitored bacterial burden based on CFU ofMycobacterium tuberculosis in lung homogenate. In an alternative approach, a recently described molecular pharmacodynamic marker called the RS ratio quantifies drug effect on a fundamental cellular process, ongoing rRNA synthesis.

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