Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model | Zendy

Kavindra V. Singh | Zendy; César A. Arias | Zendy; Barbara E. Murray | Zendy

Open Access

Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model

Author(s) -

Kavindra V. Singh,

César A. Arias,

Barbara E. Murray

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02303-19

Subject(s) - daptomycin , enterococcus faecium , enterococcus faecalis , vancomycin , medicine , staphylococcus aureus , microbiology and biotechnology , enterococcus , endocarditis , gentamicin , ceftriaxone , methicillin resistant staphylococcus aureus , antibiotics , ampicillin , bacteremia , bacteria , biology , genetics

Tedizolid (TZD) and daptomycin (DAP) were assessed in a rat endocarditis model against Enterococcus faecalis , Enterococcus faecium (resistant to vancomycin and ampicillin), and Staphylococcus aureus As a monotherapy, TZD for 5 days was not effective in a comparison with no-treatment controls, while DAP for 5 days was significantly effective against these bacteria. Step-down therapy (DAP for 3 days followed by TZD for 2 days) was as effective as DAP for 5 days and was comparable to 3 days of DAP plus ceftriaxone against all bacteria and to 3 days of DAP plus gentamicin against E. faecalis OG1RF.

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