Open AccessAspergillus terreus and the Interplay with Amphotericin B: from Resistance to Tolerance?
Author(s) -
Roya Vahedi-Shahandashti,
Anna-Maria Dietl,
Ulrike Binder,
Markus Nagl,
Reinhard Würzner,
Cornelia LassFlörl
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02274-21
Subject(s) - aspergillus terreus , amphotericin b , biology , microbiology and biotechnology , galleria mellonella , population , aspergillus , aspergillosis , fungicide , virulence , antifungal , immunology , medicine , genetics , botany , environmental health , gene
Aspergillus terreus is an opportunistic causative agent of invasive aspergillosis and, in most cases, it is refractory to amphotericin B (AMB) therapy. Notably, AMB-susceptibleAspergillus terreus sensu stricto (s.s.) representatives exist which are also associated with poor clinical outcomes.