Open AccessPopulation Pharmacokinetics of Caspofungin and Dose Simulations in Heart Transplant Recipients
Author(s) -
Zheng Wu,
Jinhua Lan,
Xipei Wang,
Youliang Wu,
Fen Yao,
Yifan Wang,
Boxin Zhao,
Yirong Wang,
Jingchun Chen,
Chunbo Chen
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02249-21
Subject(s) - caspofungin , pharmacokinetics , volume of distribution , population , medicine , pharmacology , voriconazole , antifungal , environmental health , dermatology
The effect of heart transplantation (HTx) on the pharmacokinetics (PK) of caspofungin is not well-characterized. The aim of this study was to investigate the population PK of caspofungin in HTx and non-HTx patients and to identify covariates that may affect the PK of caspofungin.