In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes | Zendy

Meredith Hackel | Zendy; James A. Karlowsky | Zendy; Michele A. Canino | Zendy; Daniel F. Sahm | Zendy; Nicole E. Scangarella-Oman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes

Author(s) -

Meredith Hackel,

James A. Karlowsky,

Michele A. Canino,

Daniel F. Sahm,

Nicole E. Scangarella-Oman

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02165-21

Subject(s) - gram , microbiology and biotechnology , agar dilution , anaerobic exercise , gram negative bacteria , gram positive bacteria , in vitro , biology , antibacterial activity , agar dilution method , agar , bacteria , anaerobic bacteria , antibiotics , minimum inhibitory concentration , escherichia coli , biochemistry , physiology , genetics , gene

Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research