Paenipeptin Analogues Potentiate Clarithromycin and Rifampin against mcr-1 -Mediated Polymyxin-Resistant Escherichia coli In Vivo | Zendy

Sun Hee Moon | Zendy; Yihong Kaufmann | Zendy; En Huang | Zendy

Open Access

Paenipeptin Analogues Potentiate Clarithromycin and Rifampin against mcr-1 -Mediated Polymyxin-Resistant Escherichia coli In Vivo

Author(s) -

Sun Hee Moon,

Yihong Kaufmann,

En Huang

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02045-19

Subject(s) - microbiology and biotechnology , escherichia coli , clarithromycin , polymyxin , polymyxin b , antibiotics , in vivo , antimicrobial , biology , antibacterial agent , gene , biochemistry

Polymyxin resistance mediated by the mcr-1 gene threatens the last-resort antibiotics. Linear lipopeptide paenipeptin analogues 1 and 15 disrupted the outer membrane of Gram-negative pathogens and potentiated clarithromycin and rifampin against mcr-1 -positive Escherichia coli from the FDA-CDC Antimicrobial Resistance Isolate Bank. In the presence of paenipeptin, clarithromycin and rifampin resulted in over 3-log reduction of E. coli in vitro Moreover, paenipeptin-antibiotic combinations significantly reduced E. coli in a murine thigh infection model.

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