Open AccessTriazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis
Author(s) -
Catherine Shelton,
Matthew B. McNeil,
Richard D. Allen,
Lindsay Flint,
Dara Russell,
Bryan J. Berube,
Aaron Korkegian,
Yulia Ovechkina,
Tanya Parish
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02041-21
Subject(s) - intracellular , mycobacterium tuberculosis , cytochrome c oxidase , mutant , microbiology and biotechnology , biology , oxidase test , cytochrome , bacteria , strain (injury) , mitochondrion , protein subunit , respiration , cellular respiration , electron transport complex iv , biochemistry , tuberculosis , enzyme , gene , genetics , medicine , botany , pathology , anatomy
We previously identified a series of triazolopyrimidines with antitubercular activity. We determined thatMycobacterium tuberculosis strains with mutations in QcrB, a subunit of the cytochromebcc-aa3 supercomplex, were resistant.