Open AccessAntivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model
Author(s) -
Fábio Aguiar-Alves,
Hoan N. Le,
Vuvi G. Tran,
Emmanuelle Gras,
Trang tin tổng hợp nhất Công nghiệp dịch vụ,
Oliver Xiaoou Dong,
Josiane Silva Quetz,
Lily Cheng,
Li Yu,
Bret R. Sellman,
C. Kendall Stover,
Antonio DiGiandomenico,
Binh An Diep
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02022-21
Subject(s) - medicine , pneumonia , ards , bacteremia , immunology , respiratory distress , lung , gastroenterology , pathology , anesthesia , microbiology and biotechnology , biology , antibiotics
Ventilator-associated pneumonia is an important clinical manifestation of the nosocomial pathogenPseudomonas aeruginosa . We characterized the correlates of protection with MEDI3902, a bispecific human IgG1 monoclonal antibody that targets theP. aeruginosa type 3 secretion system PcrV protein and the Psl exopolysaccharide, in a rabbit model of ventilator-associated pneumonia using lung-protective, low-tidal-volume mechanical ventilation.