Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model | Zendy

Fábio Aguiar-Alves | Zendy; Hoan N. Le | Zendy; Vuvi G. Tran | Zendy; Emmanuelle Gras | Zendy; Trang Vu | Zendy; Oliver Xiaoou Dong | Zendy; Josiane da Silva Quetz | Zendy; Lily Cheng | Zendy; Li Yu | Zendy; Bret R. Sellman | Zendy; C. Kendall Stover | Zendy; Antonio DiGiandomenico | Zendy; Binh An Diep | Zendy

Open Access

Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model

Author(s) -

Fábio Aguiar-Alves,

Hoan N. Le,

Vuvi G. Tran,

Emmanuelle Gras,

Trang Vu,

Oliver Xiaoou Dong,

Josiane da Silva Quetz,

Lily Cheng,

Li Yu,

Bret R. Sellman,

C. Kendall Stover,

Antonio DiGiandomenico,

Binh An Diep

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02022-21

Subject(s) - medicine , pneumonia , ards , bacteremia , immunology , respiratory distress , lung , gastroenterology , pathology , anesthesia , microbiology and biotechnology , biology , antibiotics

Ventilator-associated pneumonia is an important clinical manifestation of the nosocomial pathogenPseudomonas aeruginosa . We characterized the correlates of protection with MEDI3902, a bispecific human IgG1 monoclonal antibody that targets theP. aeruginosa type 3 secretion system PcrV protein and the Psl exopolysaccharide, in a rabbit model of ventilator-associated pneumonia using lung-protective, low-tidal-volume mechanical ventilation.

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