Open AccessNew Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae
Author(s) -
Dennis Nurjadi,
Kaan Kocer,
Quan Chanthalangsy,
Sabrina Klein,
Klaus Heeg,
Sébastien Boutin
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02011-21
Subject(s) - siderophore , enterobacter cloacae , biology , microbiology and biotechnology , cephalosporin , bacilli , enterobacter , bacteria , enterobacteriaceae , antibiotics , genetics , gene , escherichia coli
Cefiderocol is a promising novel siderophore cephalosporin for the treatment of multidrug-resistant Gram-negative bacilli and with stability against degradation by metallo-β-lactamases. Nonetheless, the emergence of cefiderocol in metallo-β-lactamase-producing Enterobacterales during therapy has been reported on more than one occasion.