Open AccessA Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes
Author(s) -
Migla Miskinyte,
John C. Dawson,
Ashraff Makda,
Dahlia Doughty-Shenton,
Neil O. Carragher,
Achim Schnaufer
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01980-21
Subject(s) - kinetoplast , biology , mitochondrial dna , genome , mitochondrion , genetics , high content screening , computational biology , dna , phenotype , microbiology and biotechnology , gene , cell
Kinetoplastid parasites cause diverse neglected diseases in humans and livestock, with an urgent need for new treatments. The survival of kinetoplastids depends on their uniquely structured mitochondrial genome (kDNA), the eponymous kinetoplast.