Open AccessIn Vitro and Intracellular Activities of Omadacycline against Legionella pneumophila
Author(s) -
Jacques Dubois,
Maïtée Dubois,
Jean-François Martel
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01972-19
Subject(s) - legionella pneumophila , legionella , legionnaires' disease , microbiology and biotechnology , intracellular , in vitro , extracellular , antibiotics , chemistry , biology , bacteria , biochemistry , genetics
Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory infections. Omadacycline exhibited extracellular activity similar to comparator antibiotics; intracellular penetrance was found by day 3 of omadacycline exposure. These results support the utility of omadacycline as an effective antibiotic for the treatment of CABP caused by L. pneumophila .