In Vitro and Intracellular Activities of Omadacycline against Legionella pneumophila | Zendy

Jacques Dubois | Zendy; Maïtée Dubois | Zendy; Jean-François Martel | Zendy

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In Vitro and Intracellular Activities of Omadacycline against Legionella pneumophila

Author(s) -

Jacques Dubois,

Maïtée Dubois,

Jean-François Martel

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01972-19

Subject(s) - legionella pneumophila , legionella , legionnaires' disease , microbiology and biotechnology , in vitro , intracellular , chemistry , biology , bacteria , biochemistry , genetics

Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory infections. Omadacycline exhibited extracellular activity similar to comparator antibiotics; intracellular penetrance was found by day 3 of omadacycline exposure. These results support the utility of omadacycline as an effective antibiotic for the treatment of CABP caused by L. pneumophila .

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