Open AccessAnti-HIV Drugs Cause Mitochondrial Dysfunction in Monocyte-Derived Macrophages
Author(s) -
Jennillee Wallace,
Hemil Gonzalez,
Reshma Rajan,
Srinivas D. Narasipura,
Amber K Virdi,
Arnold Z. Olali,
Ankur Naqib,
Zarema Arbieva,
Mark MaienscheinCline,
Lena AlHarthi
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01941-21
Subject(s) - cart , efavirenz , immunology , abacavir , transcriptome , medicine , inflammation , immune system , immune dysregulation , phenotype , population , biology , bioinformatics , antiretroviral therapy , viral load , human immunodeficiency virus (hiv) , gene , genetics , gene expression , mechanical engineering , environmental health , engineering
Combination antiretroviral therapy (cART) dramatically changed the face of the HIV/AIDS pandemic, making it one of the most prominent medical breakthroughs of the past 3 decades. However, as the life span of persons living with HIV (PLWH) continues to approach that of the general population, the same cannot be said regarding their quality of life.