Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient | Zendy

Zain Alamarat | Zendy; Jessica T. Babic | Zendy; Truc T. Tran | Zendy; Susan H. Wootton | Zendy; An Q Dinh | Zendy; William R. Miller | Zendy; Blake Hanson | Zendy; Audrey Wanger | Zendy; Joshua L. Gary | Zendy; César A. Arias | Zendy; Norma Pérez | Zendy

Open Access

Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient

Author(s) -

Zain Alamarat,

Jessica T. Babic,

Truc T. Tran,

Susan H. Wootton,

An Q Dinh,

William R. Miller,

Blake Hanson,

Audrey Wanger,

Joshua L. Gary,

César A. Arias,

Norma Pérez

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01872-19

Subject(s) - aztreonam , klebsiella pneumoniae , pseudomonas aeruginosa , medicine , osteomyelitis , ceftazidime , microbiology and biotechnology , colistin , antibiotics , cephalosporin , surgery , biology , bacteria , biochemistry , genetics , escherichia coli , gene

We report a 15 year-old Nigerian adolescent male with chronic osteomyelitis caused by an extensively drug-resistant (XDR) Pseudomonas aeruginosa strain of sequence type 773 (ST773) carrying bla NDM-1 and an extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain. The patient developed neurological side effects in the form of circumoral paresthesia with polymyxin B and asymptomatic elevation of transaminases with aztreonam (used in combination with ceftazidime-avibactam). Cefiderocol treatment for 14 weeks plus bone implantation resulted in apparent cure and avoided amputation.

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