Open AccessInhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition
Author(s) -
Masakazu Niimi,
Kyoko Niimi,
Koichi Tanabe,
Richard D. Can,
Erwin Lamping
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01748-21
Subject(s) - efflux , beauvericin , atp binding cassette transporter , mutant , biology , candida albicans , transporter , biochemistry , transmembrane domain , mutation , microbiology and biotechnology , gene , genetics , fusarium
Overexpression of ATP-binding cassette (ABC) transporters is a major cause of drug resistance in fungal pathogens. Milbemycins, enniatin B, beauvericin, and FK506 are promising leads for broad-spectrum fungal multidrug efflux pump inhibitors.