Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition | Zendy

Masakazu Niimi | Zendy; Kyoko Niimi | Zendy; Koichi Tanabe | Zendy; Richard D. Can | Zendy; Erwin Lamping | Zendy

Open Access

Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition

Author(s) -

Masakazu Niimi,

Kyoko Niimi,

Koichi Tanabe,

Richard D. Can,

Erwin Lamping

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01748-21

Subject(s) - efflux , candida albicans , transporter , mutant , atp binding cassette transporter , chemistry , substrate (aquarium) , microbiology and biotechnology , biology , pharmacology , biochemistry , gene , ecology

Overexpression of ATP-binding cassette (ABC) transporters is a major cause of drug resistance in fungal pathogens. Milbemycins, enniatin B, beauvericin, and FK506 are promising leads for broad-spectrum fungal multidrug efflux pump inhibitors.

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