Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis | Zendy

Sondus Alkhazraji | Zendy; Teclegiorgis Gebremariam | Zendy; Abdullah Alqarihi | Zendy; Yiyou Gu | Zendy; Zeinab Mamouei | Zendy; Shakti Singh | Zendy; Nathan P. Wiederhold | Zendy; Karen Joy Shaw | Zendy; Ashraf S. Ibrahim | Zendy

Open Access

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis

Author(s) -

Sondus Alkhazraji,

Teclegiorgis Gebremariam,

Abdullah Alqarihi,

Yiyou Gu,

Zeinab Mamouei,

Shakti Singh,

Nathan P. Wiederhold,

Karen Joy Shaw,

Ashraf S. Ibrahim

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01735-19

Subject(s) - fusariosis , biology , microbiology and biotechnology , prodrug , voriconazole , immunology , fusarium , antifungal , pharmacology , horticulture

There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium . Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of MGX and the efficacy of the prodrug fosmanogepix (APX001) in immunosuppressed murine models of hematogenously disseminated fusariosis and pulmonary scedosporiosis.

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