Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria | Zendy

José Luiz Fernandes Vieira | Zendy; Juan Gonzalo Bardález Rivera | Zendy; Luann Wendel Pereira de Sena | Zendy; Michelle Valéria Dias Ferreira | Zendy

Open Access

Association of Lipid Levels with Mefloquine and Carboxy-Mefloquine Concentrations in Patients with Uncomplicated Falciparum Malaria

Author(s) -

José Luiz Fernandes Vieira,

Juan Gonzalo Bardález Rivera,

Luann Wendel Pereira de Sena,

Michelle Valéria Dias Ferreira

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01731-19

Subject(s) - mefloquine , malaria , plasmodium falciparum , pharmacology , medicine , immunology

Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significant associations between the total cholesterol or triglycerides with plasma concentrations of mefloquine and of carboxy-mefloquine. Lipoprotein levels explained 25.68% and 18.31% of mefloquine and carboxy-mefloquine plasma concentrations, respectively.

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