Open AccessImpact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis
Author(s) -
Maxwell J Lasko,
Allison M Conelius,
Oscar K. Serrano,
David P. Nicolau,
Joseph L. Kuti
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01725-20
Subject(s) - cefazolin , piperacillin , medicine , ampicillin , antibiotics , vancomycin , ex vivo , surgery , autologous blood , anesthesia , in vivo , staphylococcus aureus , bacteria , microbiology and biotechnology , biology , genetics , pseudomonas aeruginosa
Intraoperative cell salvage (IOCS) is used to administer autologous blood lost during surgery. We studied antibiotic disposition through an ex vivo IOCS system for vancomycin, piperacillin, ampicillin, and cefazolin. Only 2% ± 1% of antibiotic inoculated in whole blood was recovered in the IOCS reinfusion bag, whereas 97% ± 17% was found in the waste. These observations were confirmed for ampicillin in two patients undergoing liver transplantation. Studies measuring the impact of IOCS on perioperative antibiotic concentrations are warranted.