Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis | Zendy

Maxwell J. Lasko | Zendy; Allison Conelius | Zendy; Oscar K. Serrano | Zendy; David P. Nicolau | Zendy; Joseph L. Kuti | Zendy

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Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis

Author(s) -

Maxwell J. Lasko,

Allison Conelius,

Oscar K. Serrano,

David P. Nicolau,

Joseph L. Kuti

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01725-20

Subject(s) - cefazolin , piperacillin , medicine , ampicillin , antibiotics , vancomycin , ex vivo , surgery , autologous blood , anesthesia , in vivo , staphylococcus aureus , bacteria , microbiology and biotechnology , biology , genetics , pseudomonas aeruginosa

Intraoperative cell salvage (IOCS) is used to administer autologous blood lost during surgery. We studied antibiotic disposition through an ex vivo IOCS system for vancomycin, piperacillin, ampicillin, and cefazolin. Only 2% ± 1% of antibiotic inoculated in whole blood was recovered in the IOCS reinfusion bag, whereas 97% ± 17% was found in the waste. These observations were confirmed for ampicillin in two patients undergoing liver transplantation. Studies measuring the impact of IOCS on perioperative antibiotic concentrations are warranted.

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