fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota | Zendy

Sami Khabthani | Zendy; Mouna Hamel | Zendy; Sophie Alexandra Baron | Zendy; Seydina M. Diene | Zendy; JeanMarc Rolain | Zendy; Vicky Merhej | Zendy

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fosM , a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota

Author(s) -

Sami Khabthani,

Mouna Hamel,

Sophie Alexandra Baron,

Seydina M. Diene,

JeanMarc Rolain,

Vicky Merhej

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01712-20

Subject(s) - fosfomycin , gene , microbiology and biotechnology , biology , resistance (ecology) , genetics , antibiotics , ecology

Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM .

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