Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates In Vitro and in a Mouse Model of Pulmonary Infection | Zendy

Danielle A. Nicklas | Zendy; Emily C. Maggioncalda | Zendy; Elizabeth StoryRoller | Zendy; Benjamin Eichelman | Zendy; Chavis Tabor | Zendy; Alisa W. Serio | Zendy; Tiffany R. Keepers | Zendy; Surya Chitra | Zendy; Gyanu Lamichhane | Zendy

Open Access

Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates In Vitro and in a Mouse Model of Pulmonary Infection

Author(s) -

Danielle A. Nicklas,

Emily C. Maggioncalda,

Elizabeth StoryRoller,

Benjamin Eichelman,

Chavis Tabor,

Alisa W. Serio,

Tiffany R. Keepers,

Surya Chitra,

Gyanu Lamichhane

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01704-21

Subject(s) - nontuberculous mycobacteria , mycobacterium abscessus , antibiotics , potency , medicine , pulmonary disease , tuberculosis , microbiology and biotechnology , pathogen , immunology , incidence (geometry) , in vitro , biology , mycobacterium , pathology , biochemistry , physics , optics

The incidence of nontuberculous mycobacterial diseases in the United States is rising and has surpassed that of tuberculosis. Most notable among the nontuberculous mycobacteria isMycobacteroides abscessus , an emerging environmental opportunistic pathogen capable of causing chronic infections.M. abscessus disease is difficult to treat, and the current treatment recommendations include repurposed antibiotics, several of which are associated with undesirable side effects.

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