Azole and Amphotericin B MIC Values against Aspergillus fumigatus : High Agreement between Spectrophotometric and Visual Readings Using the EUCAST EDef 9.3.2 Procedure | Zendy

Julia SerranoLobo | Zendy; Ana Gómez | Zendy; Waldo Sánchez-Yebra | Zendy; Miguel Fajardo Olivares | Zendy; Belén Huerta Lorenzo | Zendy; F Sánchez | Zendy; Inmaculada Vidal | Zendy; Marina Fernández-Torres | Zendy; Isabel SánchezRomero | Zendy; Carlos Ruiz de Alegría Puig | Zendy; José Luís del Pozo | Zendy; Patricia Muñóz | Zendy; Pilar Escribano | Zendy; Jesús Guinea | Zendy

Open Access

Azole and Amphotericin B MIC Values against Aspergillus fumigatus : High Agreement between Spectrophotometric and Visual Readings Using the EUCAST EDef 9.3.2 Procedure

Author(s) -

Julia SerranoLobo,

Ana Gómez,

Waldo Sánchez-Yebra,

Miguel Fajardo Olivares,

Belén Huerta Lorenzo,

F Sánchez,

Inmaculada Vidal,

Marina Fernández-Torres,

Isabel SánchezRomero,

Carlos Ruiz de Alegría Puig,

José Luís del Pozo,

Patricia Muñóz,

Pilar Escribano,

Jesús Guinea

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01693-20

Subject(s) - posaconazole , aspergillus fumigatus , voriconazole , amphotericin b , itraconazole , microbiology and biotechnology , azole , aspergillosis , biology , antifungal , immunology

The EUCAST EDef 9.3.2 procedure recommends visual readings of azole and amphotericin B MICs againstAspergillus spp. Visual determination of MICs may be challenging. In this work, we aim to obtain and compare visual and spectrophotometric MIC readings of azoles and amphotericin B againstAspergillus fumigatus sensu lato isolates. A total of 847A. fumigatus sensu lato isolates (A. fumigatus sensu stricto [n = 828] and cryptic species [n = 19]) were tested against amphotericin B, itraconazole, voriconazole, posaconazole, and isavuconazole using the EUCAST EDef 9.

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