Open AccessA Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses
Author(s) -
Thomas Meunier,
Lowiese Desmarets,
Simon Bordage,
Moussa Bamba,
Kévin Hervouet,
Yves Rouillé,
Nathan François,
Marion Décossas,
Valentin Sencio,
François Trottein,
Fézan Honora Tra Bi,
Olivier Lambert,
Jean Dubuisson,
Sandrine Belouzard,
Sevser Şahpaz,
Karin Séron
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01581-21
Subject(s) - virology , middle east respiratory syndrome coronavirus , coronavirus , viral envelope , vero cell , biology , viral entry , virus , viral replication , natural product , microbiology and biotechnology , covid-19 , infectious disease (medical specialty) , medicine , biochemistry , disease , pathology
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs). Here, pheophorbide a (Pba) was identified as a highly active antiviral molecule against human CoV-229E after bioguided fractionation of plant extracts.