Open AccessRNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus
Author(s) -
Jodie A. Schildkraut,
Jordy P. M. Coolen,
Sophie Burbaud,
Jasper Sangen,
Michael Kwint,
R. Andres Floto,
Huub J. M. Op den Camp,
Lindsey H M Te Brake,
Heiman Wertheim,
Kornelia Neveling,
Wouter Hoefsloot
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01509-21
Subject(s) - mycobacterium abscessus , microbiology and biotechnology , biology , regulon , transcriptome , amikacin , antibiotics , mycobacterium , genetics , gene , regulation of gene expression , bacteria , gene expression
Mycobacterium abscessus is an opportunistic pathogen notorious for its resistance to most classes of antibiotics and low cure rates.M. abscessus carries an array of mostly unexplored defense mechanisms. A deeper understanding of antibiotic resistance and tolerance mechanisms is pivotal in development of targeted therapeutic regimens.