RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus | Zendy

Jodie A. Schildkraut | Zendy; Jordy P. M. Coolen | Zendy; Sophie Burbaud | Zendy; Jasper Sangen | Zendy; Michael Kwint | Zendy; R. Andres Floto | Zendy; Huub J. M. Op den Camp | Zendy; Lindsey H. M. te Brake | Zendy; Heiman Wertheim | Zendy; Kornelia Neveling | Zendy; Wouter Hoefsloot | Zendy; Jakko van Ingen | Zendy

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RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus

Author(s) -

Jodie A. Schildkraut,

Jordy P. M. Coolen,

Sophie Burbaud,

Jasper Sangen,

Michael Kwint,

R. Andres Floto,

Huub J. M. Op den Camp,

Lindsey H. M. te Brake,

Heiman Wertheim,

Kornelia Neveling,

Wouter Hoefsloot,

Jakko van Ingen

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01509-21

Subject(s) - mycobacterium abscessus , microbiology and biotechnology , biology , regulon , transcriptome , amikacin , antibiotics , mycobacterium , genetics , gene , regulation of gene expression , bacteria , gene expression

Mycobacterium abscessus is an opportunistic pathogen notorious for its resistance to most classes of antibiotics and low cure rates.M. abscessus carries an array of mostly unexplored defense mechanisms. A deeper understanding of antibiotic resistance and tolerance mechanisms is pivotal in development of targeted therapeutic regimens.

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