Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest | Zendy

Kay B. Barnes | Zendy; Steven D. Zumbrun | Zendy; Stephanie Halasohoris | Zendy; Purvi D. Desai | Zendy; Lynda L. Miller | Zendy; Mark I. Richards | Zendy; Paul F. Russell | Zendy; Christine Bentley | Zendy; Sarah V. Harding | Zendy

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Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest

Author(s) -

Kay B. Barnes,

Steven D. Zumbrun,

Stephanie Halasohoris,

Purvi D. Desai,

Lynda L. Miller,

Mark I. Richards,

Paul F. Russell,

Christine Bentley,

Sarah V. Harding

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01470-19

Subject(s) - broth microdilution , antimicrobial , in vivo , in vitro , biodefense , broad spectrum , microbiology and biotechnology , antibiotics , in vitro toxicology , biology , chemistry , minimum inhibitory concentration , biochemistry , combinatorial chemistry

This study investigated the in vitro activity of finafloxacin against panels of the biodefence pathogens. Broth microdilution assays were performed at neutral and acidic pH, to determine the effectiveness of the antibiotics in conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH. These results highlight the importance of evaluating antimicrobial efficacy in conditions relevant to those encountered in vivo .

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