In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria | Zendy

Akinobu Ito | Zendy; Takafumi Sato | Zendy; Merime Ota | Zendy; Miki Takemura | Zendy; Toru Nishikawa | Zendy; Shinsuke Toba | Zendy; Naoki Kohira | Zendy; Satoshi Miyagawa | Zendy; Naoki Ishibashi | Zendy; Shuhei Matsumoto | Zendy; Rio Nakamura | Zendy; Masakatsu Tsuji | Zendy; Yoshinori Yamano | Zendy

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In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria

Author(s) -

Akinobu Ito,

Takafumi Sato,

Merime Ota,

Miki Takemura,

Toru Nishikawa,

Shinsuke Toba,

Naoki Kohira,

Satoshi Miyagawa,

Naoki Ishibashi,

Shuhei Matsumoto,

Rio Nakamura,

Masakatsu Tsuji,

Yoshinori Yamano

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01454-17

Subject(s) - siderophore , microbiology and biotechnology , pseudomonas aeruginosa , cephalosporin , acinetobacter baumannii , biology , enterobacteriaceae , efflux , klebsiella pneumoniae , escherichia coli , bacteria , serratia , antibiotics , pseudomonas , biochemistry , gene , genetics

Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii Cefiderocol has affinity mainly for penicillin-binding protein 3 (PBP3) of Enterobacteriaceae and nonfermenting bacteria similar to that of ceftazidime. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli caused 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa showed no significant impact on the activity of cefiderocol.

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