Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals | Zendy

Xiao Yu | Zendy; Beiwen Zheng | Zendy; Jing Zhang | Zendy; Hao Xu | Zendy; Tingting Xiao | Zendy; Yanzi Zhou | Zendy; Shuntian Zhang | Zendy; Yunying Zhu | Zendy; Yuan Wang | Zendy; Yonghong Xiao | Zendy

Open Access

Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals

Author(s) -

Xiao Yu,

Beiwen Zheng,

Jing Zhang,

Hao Xu,

Tingting Xiao,

Yanzi Zhou,

Shuntian Zhang,

Yunying Zhu,

Yuan Wang,

Yonghong Xiao

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01367-19

Subject(s) - transposable element , carbapenem , mobile genetic elements , biology , multiple drug resistance , genome , microbiology and biotechnology , gene , genetics , antibiotics

We report the characterization of six carbapenem-resistant Raoultella spp. (CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistant genes from the hospital. An improved understanding of these transposon and targeted control measures will be very valuable to prevent the CRRS dissemination.

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