Open AccessSusceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials
Author(s) -
Sara Ceballos,
Choon Kim,
Yuanyuan Qian,
Shahriar Mobashery,
Mayland Chang,
Cármen Torres
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01344-19
Subject(s) - staphylococcus aureus , antibiotics , microbiology and biotechnology , quinazolinone , methicillin resistant staphylococcus aureus , meticillin , antibacterial agent , micrococcaceae , medicine , biology , bacteria , chemistry , genetics , combinatorial chemistry
The in vitro activities of five quinazolinone antibacterials, compounds Q1 to Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC 50 /MIC 90 values (in μg/ml) were as follows: Q1, 0.5/2; Q2, 1/4; Q3, 2/4; Q4, 0.06/0.25; and Q5, 0.125/0.5. Several strains with high MIC values (from 8 to >32 μg/ml) for some of these compounds exhibited amino acid changes in the penicillin-binding proteins, which are targeted by these antibacterials.