Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B | Zendy

Jitender Yadav | Zendy; Sana Ismaeel | Zendy; Ayub Qadri | Zendy

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Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B

Author(s) -

Jitender Yadav,

Sana Ismaeel,

Ayub Qadri

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01337-20

Subject(s) - polymyxin , polymyxin b , microbiology and biotechnology , bacteria , lysophosphatidylcholine , antibiotics , gram negative bacteria , aminoglycoside , chemistry , pharmacology , colistin , biology , biochemistry , escherichia coli , membrane , phospholipid , genetics , phosphatidylcholine , gene

Polymyxin B, used to treat infections caused by antibiotic-resistant Gram-negative bacteria, produces nephrotoxicity at its current dosage. We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of Salmonella and at least two other Gram-negative bacteria in vitro This combination makes bacterial membrane porous and causes degradation of DnaK, the regulator of protein folding. Polymyxin B-LPC combination may be an effective and safer regimen against drug-resistant bacteria.

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