Open AccessLysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B
Author(s) -
Jitender Yadav,
Sana Ismaeel,
Ayub Qadri
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01337-20
Subject(s) - polymyxin , polymyxin b , microbiology and biotechnology , bacteria , lysophosphatidylcholine , antibiotics , gram negative bacteria , aminoglycoside , chemistry , pharmacology , biology , biochemistry , escherichia coli , membrane , phospholipid , genetics , phosphatidylcholine , gene
Polymyxin B, used to treat infections caused by antibiotic-resistant Gram-negative bacteria, produces nephrotoxicity at its current dosage. We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of Salmonella and at least two other Gram-negative bacteria in vitro This combination makes bacterial membrane porous and causes degradation of DnaK, the regulator of protein folding. Polymyxin B-LPC combination may be an effective and safer regimen against drug-resistant bacteria.