Effect of High N -Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens | Zendy

Giulia Landini | Zendy; Tiziana Di Maggio | Zendy; Francesco Sergio | Zendy; JeanDenis Docquier | Zendy; Gian María Rossolini | Zendy; Lucia Pallecchi | Zendy

Open Access

Effect of High N -Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens

Author(s) -

Giulia Landini,

Tiziana Di Maggio,

Francesco Sergio,

JeanDenis Docquier,

Gian María Rossolini,

Lucia Pallecchi

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01334-16

Subject(s) - ertapenem , imipenem , meropenem , antibiotics , acetylcysteine , microbiology and biotechnology , ceftriaxone , pneumonia , cephalosporin , antibacterial agent , pharmacology , medicine , chemistry , biology , antibiotic resistance , biochemistry , antioxidant

The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity.

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