Open AccessPlanktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections
Author(s) -
Georg Zhuchenko,
Suzannah M. Schmidt-Malan,
Robin Patel
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01304-20
Subject(s) - staphylococcus epidermidis , microbiology and biotechnology , biofilm , periprosthetic , staphylococcus aureus , micrococcaceae , methicillin resistant staphylococcus aureus , staphylococcus , staphylococcal infections , joint infections , biology , chemistry , medicine , antibiotics , antibacterial agent , bacteria , arthroplasty , surgery , genetics
MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC 50 and MBBC 90 values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.