In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis | Zendy

Matthew B. McNeil | Zendy; Devon Dennison | Zendy; Catherine Shelton | Zendy; Tanya Parish | Zendy

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In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis

Author(s) -

Matthew B. McNeil,

Devon Dennison,

Catherine Shelton,

Tanya Parish

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01296-17

Subject(s) - 23s ribosomal rna , mycobacterium tuberculosis , microbiology and biotechnology , chloramphenicol , biology , linezolid , tuberculosis , ribosomal rna , antibiotics , virology , mutant , in vitro , bacteria , genetics , medicine , gene , rna , vancomycin , ribosome , staphylococcus aureus , pathology

Oxazolidinones are promising candidates for the treatment of Mycobacterium tuberculosis infections. We isolated linezolid-resistant strains from H37Rv (Euro-American) and HN878 (East-Asian) strains; resistance frequencies were similar in the two strains. Mutations were identified in ribosomal protein L3 (RplC) and the 23S rRNA ( rrl ). All mutant strains were cross resistant to sutezolid; a subset was cross resistant to chloramphenicol. Mutations in rrl led to growth impairment and decreased fitness that may limit spread in clinical settings.

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