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We have identified the first case of an fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafungin treatment.

antimicrobial agents and chemotherapy

Emergence of Echinocandin Resistance Due to a Point Mutation in the <i>fks1</i> Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis

Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis