Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis | Zendy

Cristina JiménezOrtigosa | Zendy; Caroline M. Moore | Zendy; David W. Denning | Zendy; David S. Perlin | Zendy

Open Access

Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis

Author(s) -

Cristina JiménezOrtigosa,

Caroline M. Moore,

David W. Denning,

David S. Perlin

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01277-17

Subject(s) - aspergillus fumigatus , echinocandin , aspergillosis , pulmonary aspergillosis , point mutation , aspergillus , microbiology and biotechnology , mutation , medicine , drug resistance , gene , biology , intensive care medicine , antifungal , genetics , immunology , fluconazole

We have identified the first case of an fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafungin treatment.

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