The Class A Carbapenemases BKC-1 and GPC-1 Both Originate from the Bacterial Genus Shinella | Zendy

Nicolas Kieffer | Zendy; Stefan Ebmeyer | Zendy; D. G. Joakim Larsson | Zendy

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The Class A Carbapenemases BKC-1 and GPC-1 Both Originate from the Bacterial Genus Shinella

Author(s) -

Nicolas Kieffer,

Stefan Ebmeyer,

D. G. Joakim Larsson

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01263-20

Subject(s) - biology , gene , homology (biology) , escherichia coli , gene duplication , genetics , homologous chromosome , enterobacteriaceae , microbiology and biotechnology , comparative genomics , genome , genomics

Comparative genomics identified the environmental bacterial genus Shinella as the most likely origin of the class A carbapenemases BKC-1 and GPC-1. Available sequences and PCR analyses of additional Shinella species revealed homologous β-lactamases showing up to 85.4% and 93.3% amino acid identity to both enzymes, respectively. The genes conferred resistance to β-lactams once expressed in Escherichia coli bla BKC-1 likely evolved from a putative ancestral Shinella gene with higher homology through duplication of a gene fragment.

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