Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance | Zendy

Takeshi Shimizu | Zendy; Tohru MiyoshiAkiyama | Zendy; Kohei Ogura | Zendy; Shota Murata | Zendy; Shota Ishige | Zendy; Kiyohiro Kai | Zendy; Konosuke Mitsutsuka | Zendy; Haruyoshi Tomita | Zendy; Koichi Tanimoto | Zendy; Akio Matsumoto | Zendy

Open Access

Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance

Author(s) -

Takeshi Shimizu,

Tohru MiyoshiAkiyama,

Kohei Ogura,

Shota Murata,

Shota Ishige,

Kiyohiro Kai,

Konosuke Mitsutsuka,

Haruyoshi Tomita,

Koichi Tanimoto,

Akio Matsumoto

Publication year - 2020

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01180-20

Subject(s) - pseudomonas aeruginosa , clarithromycin , microbiology and biotechnology , erythromycin , josamycin , macrolide antibiotics , multiple drug resistance , antibiotics , nitric oxide , pharmacology , chemistry , medicine , biology , bacteria , genetics

Sub-MICs of the 14-membered macrolides erythromycin (EM) and clarithromycin (CAM) decreased the growth of Pseudomonas aeruginosa PAO1 and increased its sensitivity to endogenous and exogenous nitrosative stress. However, a 16-membered macrolide, josamycin (JM), was not or less effective. In 9 of 13 non-multidrug-resistant P. aeruginosa (non-MDRP) and 9 of 27 MDRP ST235 strains, the sub-MIC of EM induced significant reductions in bacterial numbers following treatment with a nitric oxide donor.

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