Open AccessEffect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance
Author(s) -
Takeshi Shimizu,
Tohru MiyoshiAkiyama,
Kohei Ogura,
Shota Murata,
Shota Ishige,
Kiyohiro Kai,
Konosuke Mitsutsuka,
Haruyoshi Tomita,
Koichi Tanimoto,
Akio Matsumoto
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01180-20
Subject(s) - pseudomonas aeruginosa , clarithromycin , microbiology and biotechnology , erythromycin , josamycin , macrolide antibiotics , multiple drug resistance , antibiotics , nitric oxide , pharmacology , chemistry , medicine , biology , bacteria , genetics
Sub-MICs of the 14-membered macrolides erythromycin (EM) and clarithromycin (CAM) decreased the growth of Pseudomonas aeruginosa PAO1 and increased its sensitivity to endogenous and exogenous nitrosative stress. However, a 16-membered macrolide, josamycin (JM), was not or less effective. In 9 of 13 non-multidrug-resistant P. aeruginosa (non-MDRP) and 9 of 27 MDRP ST235 strains, the sub-MIC of EM induced significant reductions in bacterial numbers following treatment with a nitric oxide donor.