Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing | Zendy

Mariko Kanai | Zendy; Tomas Yeo | Zendy; Victor Asua | Zendy; Philip J. Rosenthal | Zendy; David A. Fidock | Zendy; Sachel Mok | Zendy

Open Access

Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing

Author(s) -

Mariko Kanai,

Tomas Yeo,

Victor Asua,

Philip J. Rosenthal,

David A. Fidock,

Sachel Mok

Publication year - 2021

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01163-21

Subject(s) - genotyping , biology , plasmodium falciparum , microsatellite , genome , genetics , typing , snp genotyping , computational biology , single nucleotide polymorphism , molecular inversion probe , snp , snp array , whole genome sequencing , genotype , malaria , gene , allele , immunology

Research efforts to combat antimalarial drug resistance rely on quick, robust, and sensitive methods to genetically characterizePlasmodium falciparum parasites. We developed a single-nucleotide polymorphism (SNP)-based genotyping method that can assess 33 drug resistance-conferring SNPs indhfr, dhps, pfmdr1, pfcrt, andk13 in nine PCRs, performed directly fromP. falciparum cultures or infected blood.

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