Open AccessIn VitroActivity of Tedizolid Compared to Linezolid and Five Other Antimicrobial Agents against 332 Anaerobic Isolates, Including Bacteroides fragilis Group,Prevotella,Porphyromonas, andVeillonellaSpecies
Author(s) -
Goldstein Ej,
C. Vreni Merriam,
Diane M. Citron
Publication year - 2020
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01088-20
Subject(s) - bacteroides fragilis , microbiology and biotechnology , veillonella , linezolid , antimicrobial , prevotella , bacteroides , anaerobic exercise , anaerobic bacteria , biology , chemistry , antibiotics , bacteria , streptococcus , staphylococcus aureus , vancomycin , physiology , genetics
Tedizolid's anaerobic activity is unappreciated. In this study, it was active against all 332 anaerobic isolates tested at ≤2 μg/ml except Bilophila wadsworthia and was more active than linezolid against Bacteroides fragilis group species (MIC 90 , 1 μg/ml versus 2 to 4 μg/ml). Tedizolid was active against Gram-positive anaerobes (MIC 90 for clostridia, 0.25 to 1 μg/ml; MIC 90 for anaerobic cocci, ≤0.06 to 0.25 μg/ml). Our data coupled with clinical reports indicate that clinicians should consider its use in mixed infections where Staphylococcus aureus and anaerobes are involved.